Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
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چکیده
منابع مشابه
Vimentin regulates activation of the NLRP3 inflammasome
Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require NLRP3 inflammasome activation. We demonstrate that central pathophysiologic eve...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2013
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2012.11.009